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Article

GM-CSF receptor expression determines opposing innate memory phenotypes at different stages of myelopoiesis.

Blood - 27 Jun 2024

Guerrero Paula, Bono Cristina, Sobén María, Guiu Andrea, Cheng Quen J, Gil M Luisa, Yáñez Alberto

Abstract excerpt

ABSTRACT: Inflammatory responses must be tightly coordinated with the activation of emergency myelopoiesis to produce potent myeloid cells that fight infection without causing excessive host damage. Here, we show that granulocyte-macrophage colony-stimulating factor (GM-CSF) programs myeloid-committed progenitors to produce trained macrophages (increased cytokine response), but programs the upstream noncommitted...

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Source

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Identifiers

PMID: 38603633
DOI: 10.1182/blood.2024024330
PMCID: PMC11251219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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