Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased mutation frequency in redox-impaired Escherichia coli due to RelA- and RpoS-mediated repression of DNA repair.

Applied and environmental microbiology - 1 Aug 2010

Singh Amarjeet, Karimpour-Fard Anis, Gill Ryan T

Abstract excerpt

Balancing of reducing equivalents is a fundamental issue in bacterial metabolism and metabolic engineering. Mutations in the key metabolic genes ldhA and pflB of Escherichia coli are known to stall anaerobic growth and fermentation due to a buildup of intracellular NADH. We observed that the rate of spontaneous mutation in E. coli BW25113 (DeltaldhA DeltapflB) was an order of magnitude higher than that in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetyltransferases
Share to DNA Repair
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to L-Lactate Dehydrogenase

Share to Ligases

Share to Oxidation-Reduction

Share to Sigma Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 20581184
DOI: 10.1128/AEM.00583-10
PMCID: PMC2918982

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased mutation frequency in redox-impaired Escherichia coli due to RelA- and RpoS-mediated repression of DNA repair.PMID 20581184Read ↗

OxyR Is a Convergent Target for Mutations Acquired during Adaptation to Oxidative Stress-Prone Metabolic States.Semantic proximity Read ↗

Persistent damaged bases in DNA allow mutagenic break repair in Escherichia coli.Semantic proximity Read ↗

Experimental evolution reveals the genetic basis and systems biology of superoxide stress toleranceSemantic proximity Read ↗

What limits the efficiency of double-strand break-dependent stress-induced mutation in Escherichia coli?Semantic proximity Read ↗

Redox stress agents strongly enhance mutagenesis during horizontal gene transfer in bacteria and leave distinct mutational and metabolic footprintsSemantic proximity Read ↗

Evidence for up and down regulation of 450 genes by rpoB12 (rif) mutation and their implications in complexity of transcription modulation in Escherichia coli.Semantic proximity Read ↗

Stress-induced mutagenesis in bacteria.Semantic proximity Read ↗

Oxygen and RNA in stress-induced mutation.Semantic proximity Read ↗

Separate DNA Pol II- and Pol IV-dependent pathways of stress-induced mutation during double-strand-break repair in Escherichia coli are controlled by RpoS.Semantic proximity Read ↗

Evolution, genomic analysis, and reconstruction of isobutanol tolerance in Escherichia coli.Semantic proximity Read ↗

Transcription factor R ex in regulation of pathophysiology in oral pathogensSemantic proximity Read ↗

Evolution combined with genomic study elucidates genetic bases of isobutanol tolerance in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.