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Article

Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension.

Circulation - 8 Feb 2005

Machado Rajiv D, James Victoria, Southwood Mark, Harrison Rachel E, Atkinson Carl, Stewart Susan, Morrell Nicholas W, Trembath Richard C, Aldred Micheala A

Abstract excerpt

BACKGROUND: Primary pulmonary arterial hypertension (PAH) is a potentially devastating condition resulting from occlusion of the pulmonary arterioles by the formation of vascular lesions. Heterozygous mutations in the gene encoding the bone morphogenetic protein receptor type II (BMPR2) have been...

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Share to Bone Morphogenetic Protein Receptors, Type II
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypertension, Pulmonary

Share to Loss of Heterozygosity

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Share to Mutation, Missense

Share to Protein Serine-Threonine Kinases

Source

Identifiers

PMID: 15699281
DOI: 10.1161/01.CIR.0000154543.07679.08

Genes

BMPR2
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15699281-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension.PMID 15699281Read ↗

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