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Article

Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck.

Cancer - 15 May 2010

Li Fanglin, Sturgis Erich M, Chen Xingming, Zafereo Mark E, Wei Qingyi, Li Guojun

Abstract excerpt

BACKGROUND: p53 plays a critical role in cellular anticancer mechanisms, and has been correlated with second primary malignancy (SPM) development. A common polymorphism in codon 72 of p53 results in an amino acid substitution and could influence p53 function. The authors hypothesized that p53 codon 72 polymorphism may be associated with risk of SPMs and SPM-free survival among patients with squamous cell...

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Share to Aged, 80 and over
Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to Head and Neck Neoplasms

Share to Neoplasms, Second Primary

Share to Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 20225330
DOI: 10.1002/cncr.25072
PMCID: PMC2864328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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