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Association of Polymorphisms of the Tissue Inhibitors of Metalloproteinases- 1 and -2 with Alzheimer's Disease in Taiwan.

Current Alzheimer research - 1 Jan 2021

Ho Wei-Min, Lee Yun-Shien, Chen Chiung-Mei, Wu Yah-Yuan, Hsu Wen-Chuin, Huang Yu-Hua, Chen Yi-Chun

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) leads to progressive neuronal loss and cognitive and behavioral decline in the aging population. Matrix metalloproteinases (MMPs) and associated tissue inhibitors of metalloproteinases (TIMPs) are involved in remodeling the extracellular matrix. Amyloid beta-42 interrupts the integrity of the neurovascular unit and induces a toxic reaction affecting neurons. OBJECTIVE: This...

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PMID: 34561981
DOI: 10.2174/1567205018666210924095818

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