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Matrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders

31 Mar 2012

Abstract excerpt

Matrix metalloproteinases (MMPs) are a subfamily of zinc-dependent proteases that are responsible for degradation and remodeling of extracellular matrix proteins. The activity of MMPs is tightly regulated at several levels including cleavage of prodomain, allosteric activation, compartmentalization and complex formation with tissue inhibitor of metalloproteinases (TIMPs). In the central nervous system (CNS), MMPs...

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PMID: 24116286
DOI: 10.4062/biomolther.2012.20.2.133

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