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Article

Omeprazole-induced acute interstitial nephritis is not related to CYP2C19 genotype or CYP2C19 phenotype.

British journal of clinical pharmacology - 1 May 2010

Helsby Nuala A, Lo Wing-Yee, Simpson Ian J, Voss David M, Logan Kaye E, Searle Martin, Schollum John B W, de Zoysa Janak R

Abstract excerpt

AIM: Omeprazole-induced acute interstitial nephritis (OIAIN) is a rare adverse event. It is unknown if this is an idiosyncratic immune mediated reaction or if it relates to direct drug toxicity. Individuals who are homozygous for the variant alleles of CYP2C19 are poor metabolizers of omeprazole and have a greater exposure to the drug. The aim of this study was to determine the prevalence of the CYP2C19 poor...

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Source

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Identifiers

PMID: 20573087
DOI: 10.1111/j.1365-2125.2010.03623.x
PMCID: PMC2856052

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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