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Article

Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas

15 Aug 2011

Abstract excerpt

BACKGROUND: Malignant gliomas are the most common in central nervous system cancer. Genome-wide association study identifies that CDKN2A was a susceptibility loci for glioma. The CDKN2A/cyclin-dependent kinase 4, 6/Retinoblastoma protein (Rb) pathway is thought to play a crucial role in malignant gliomas pathogenesis. We have investigated the expression of CDKN2A for potential correlations with malignant gliomas...

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PMID: 21843312
DOI: 10.1186/1756-9966-30-76

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