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Article

A flexible and efficient template format for circular consensus sequencing and SNP detection.

Nucleic acids research - 1 Aug 2010

Travers Kevin J, Chin Chen-Shan, Rank David R, Eid John S, Turner Stephen W

Abstract excerpt

A novel template design for single-molecule sequencing is introduced, a structure we refer to as a SMRTbell template. This structure consists of a double-stranded portion, containing the insert of interest, and a single-stranded hairpin loop on either end, which provides a site for primer binding. Structurally, this format resembles a linear double-stranded molecule, and yet it is topologically circular. When...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20571086
DOI: 10.1093/nar/gkq543
PMCID: PMC2926623

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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