Article
Consensus generation and variant detection by Celera Assembler.
Bioinformatics (Oxford, England) - 15 Apr 2008
Denisov Gennady, Walenz Brian, Halpern Aaron L, Miller Jason, Axelrod Nelson, Levy Samuel, Sutton Granger
Abstract excerpt
MOTIVATION: We present an algorithm to identify allelic variation given a Whole Genome Shotgun (WGS) assembly of haploid sequences, and to produce a set of haploid consensus sequences rather than a single consensus sequence. Existing WGS assemblers take a column-by-column approach to consensus generation, and produce a single consensus sequence which can be inconsistent with the underlying haploid alleles, and...
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