Article
Combining the FLT3 inhibitor PKC412 and the triterpenoid CDDO-Me synergistically induces apoptosis in acute myeloid leukemia with the internal tandem duplication mutation.
Molecular cancer research : MCR - 1 Jul 2010
Ahmad Rehan, Liu Suiyang, Weisberg Ellen, Nelson Erik, Galinsky Ilene, Meyer Colin, Kufe Donald, Kharbanda Surender, Stone Richard
Abstract excerpt
Mutations of the FLT3 receptor tyrosine kinase consisting of internal tandem duplications (ITD) have been detected in blasts from 20% to 30% of patients with acute myeloid leukemia (AML) and are associated with a poor prognosis. FLT3/ITD results in constitutive autophosphorylation of the receptor and factor-independent survival in leukemia cell lines. The C-28 methyl ester of the oleane triterpenoid (CDDO-Me) is...
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