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Article

Effect of Quizartinib on the Resistance of Acute Myeloid Leukemia Cells with FLT3-ITD-Positive and FLT3-ITD-Negative Phenotypes to the TRAIL-Induced Apoptosis.

Biochemistry. Biokhimiia - 1 Jan 2026

Kobyakova Margarita I, Lomovskaya Yana V, Krasnov Kirill S, Odinokova Irina V, Meshcheriakova Elena I, Ermakov Artem M, Didenko Alina S, Senotov Anatoly S, Fadeeva Irina S, Fadeev Roman S

Abstract excerpt

Internal tandem duplications in the gene encoding the membrane domain of FLT3 (FLT3-ITD) are the most common genetic alteration and an unfavorable prognostic factor in the patients with acute myeloid leukemia (AML). New-generation FLT3 inhibitors effectively induce cell death in the AML cells with the FLT3-ITD-positive phenotype (FLT3-ITD+) and potentially exhibit cytotoxic activity against the AML cells with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41702735
DOI: 10.1134/S000629792560276X

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Effect of Quizartinib on the Resistance of Acute Myeloid Leukemia Cells with FLT3-ITD-Positive and FLT3-ITD-Negative Phenotypes to the TRAIL-Induced Apoptosis.PMID 41702735Read ↗

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Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia modelsSemantic proximity Read ↗

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The TP53 Apoptotic Network Is a Primary Mediator of Resistance to BCL2 Inhibition in AML CellsSemantic proximity Read ↗

Selective FLT3 inhibitor FI-700 neutralizes Mcl-1 and enhances p53-mediated apoptosis in AML cells with activating mutations of FLT3 through Mcl-1/Noxa axis.Semantic proximity Read ↗

AML under the Scope: Current Strategies and Treatment Involving FLT3 Inhibitors and Venetoclax-Based Regimens.Semantic proximity Read ↗

All-trans retinoic acid potentiates cell death induced by quizartinib in acute myeloid leukemia with FLT3-ITD mutations.Semantic proximity Read ↗

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Heterogeneous resistance to quizartinib in acute myeloid leukemia revealed by single-cell analysisSemantic proximity Read ↗

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