Article
Combined inhibition of Notch and FLT3 produces synergistic cytotoxic effects in FLT3/ITD+ acute myeloid leukemia.
Signal transduction and targeted therapy - 13 Mar 2020
Li Dan, Li Tongjuan, Shang Zhen, Zhao Lei, Xu Qian, Tan Jiaqi, Qin Yun, Zhang Yuanyuan, Cao Yang, Wang Na, Huang Liang, Zhu Xiaojian, Zhou Kuangguo, Chen Liting, Li Chunrui, Xie Ting, Yang Yi, Wang Jue, Zhou Jianfeng
Abstract excerpt
Internal tandem duplication (ITD) mutations of FMS-like tyrosine kinase-3 (FLT3) are the most frequent genetic alterations in acute myeloid leukemia (AML) and predict a poor prognosis. FLT3 tyrosine kinase inhibitors (TKIs) provide short-term clinical responses, but the long-term prognosis of FLT3/ITD+ AML patients remains poor. Notch signaling is important in numerous types of tumors. However, the role of Notch...
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