Combined inhibition of PI3Kδ and FLT3 signaling exerts synergistic antitumor activity and overcomes acquired drug resistance in FLT3-activated acute myeloid leukemia.

doi:10.1016/j.canlet.2018.01.071

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Article

Combined inhibition of PI3Kδ and FLT3 signaling exerts synergistic antitumor activity and overcomes acquired drug resistance in FLT3-activated acute myeloid leukemia.

Cancer letters - 28 Apr 2018

He Ye, Sun Liping, Xu Yongping, Fu Li, Li Yun, Bao Xubin, Fu Haoyu, Xie Chengying, Lou Liguang

Abstract excerpt

PI3Kδ and FLT3 are frequently activated in acute myeloid leukemia (AML) and have been implicated as potential therapeutic targets. In this report, we demonstrate that combined inhibition of PI3Kδ and FLT3 exerts synergistic antitumor activity in FLT3-activated AML. Synergistic antiproliferative effects were observed in FLT3-activated MV-4-11 and EOL-1 AML cell lines, but not in FLT3-independent RS4;11 and HEL...

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PMID: 29409989
DOI: 10.1016/j.canlet.2018.01.071

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FLT3

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