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Article

NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Sept 2010

Zamorano Laura, Reeve Thomas M, Deng Lehua, Juan Carlos, Moyá Bartolomé, Cabot Gabriel, Vocadlo David J, Mark Brian L, Oliver Antonio

Abstract excerpt

AmpC hyperproduction is the most frequent mechanism of resistance to penicillins and cephalosporins in Pseudomonas aeruginosa and is driven by ampD mutations or the recently described inactivation of dacB, which encodes the nonessential penicillin-binding protein (PBP) PBP 4. Recent work showed t...

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Identifiers

PMID: 20566764
DOI: 10.1128/AAC.00385-10
PMCID: PMC2934985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20566764-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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NagZ inactivation prevents and reverts beta-lactam resistance, driven by AmpD and PBP 4 mutations, in Pseudomonas aeruginosa.PMID 20566764Read ↗

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