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Article

Tacrolimus nephrotoxicity: beware of the association of diarrhea, drug interaction and pharmacogenetics.

Pediatric nephrology (Berlin, Germany) - 1 May 2010

Leroy Sandrine, Isapof Arnaud, Fargue Sonia, Fakhoury May, Bensman Albert, Deschênes Georges, Jacqz-Aigrain Evelyne, Ulinski Tim

Abstract excerpt

Tacrolimus is known to potentially lead to adverse events in recipients with diarrhoea and/or calcium channel blocker (CCB) co-administration. We report a renal transplant recipient who suffered from severe nephrotoxicity related to a toxic tacrolimus trough concentration in both conditions, diarrhoea and CCB co-administration, and with genotyped CYP3A system and P-glycoprotein (P-gp) polymorphisms. To our...

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Identifiers

PMID: 20091056
DOI: 10.1007/s00467-009-1402-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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