Article
The pharmacogenetics of mycophenolate mofetil in Tunisian renal transplant patients.
Personalized medicine - 1 Sept 2022
Abderahmene Amani, Ellouz Amel, Amor Dorra, Ajmi Marwa, Khalij Yassine, Hamdouni Haithem, Sahtout Wissal, Azzabi Awatef, Omezzine Asma, Achour Abdellatif, Bouslama Ali
Abstract excerpt
Aim: The effects of variants in IMPDH, UGT1A9, UGT1A8, UGT2B7 and SLCO1B1 genes on the efficacy and safety of mycophenolate mofetil (MMF) in the Tunisian population were investigated. Materials & methods: A total of 245 kidney transplant patients being treated with MMF were recruited and cotreated with cyclosporine or tacrolimus. Genotyping was performed using the polymerase chain reaction-restriction fragment...
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