Article
Association of genetic risk variants with expression of proximal genes identifies novel susceptibility genes for cardiovascular disease.
Circulation. Cardiovascular genetics - 1 Aug 2010
Folkersen Lasse, van't Hooft Ferdinand, Chernogubova Ekaterina, Agardh Hanna E, Hansson Göran K, Hedin Ulf, Liska Jan, Syvänen Ann-Christine, Paulsson-Berne Gabrielle, Paulssson-Berne Gabrielle, Franco-Cereceda Anders, Hamsten Anders, Gabrielsen Anders, Eriksson Per
Abstract excerpt
BACKGROUND: Population-based genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with cardiovascular disease or its risk factors. Genes in close proximity to these risk-SNPs are often thought to be pathogenetically important based on their location alone. However, the actual connections between SNPs and disease mechanisms remain largely unknown. METHODS AND...
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