Article
Genome-wide high-resolution screening in Dupuytren's disease reveals common regions of DNA copy number alterations.
The Journal of hand surgery - 1 Jul 2010
Shih Barbara B, Tassabehji May, Watson James S, McGrouther Angus D, Bayat Ardeshir
Abstract excerpt
PURPOSE: Dupuytren's disease (DD) is a familial disorder with a high genetic susceptibility in white people; however, its etiopathogenesis remains unknown. Previous comparative genomic hybridization studies using lower-resolution, 44-k oligonucleotide-based arrays revealed no copy number variation (CNV) changes in DD. In this study, we used a higher-resolution genome-wide screening (next-generation microarrays)...
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