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Article

Structural dynamics of HIV-1 envelope Gp120 outer domain with V3 loop.

PloS one - 1 Jan 2012

Yokoyama Masaru, Naganawa Satoshi, Yoshimura Kazuhisa, Matsushita Shuzo, Sato Hironori

Abstract excerpt

BACKGROUND: The net charge of the hypervariable V3 loop on the HIV-1 envelope gp120 outer domain plays a key role in modulating viral phenotype. However, the molecular mechanisms underlying the modulation remain poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: By combining computational and experimental approaches, we examined how V3 net charge could influence the phenotype of the gp120 interaction surface....

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Identifiers

PMID: 22624045
DOI: 10.1371/journal.pone.0037530
PMCID: PMC3356331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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