Article
SNPs in the HIV-1 TATA box and the AIDS pandemic.
Journal of bioinformatics and computational biology - 1 Jun 2010
Suslov Valentin V, Ponomarenko Petr M, Efimov Vadim M, Savinkova Ludmila K, Ponomarenko Mikhail P, Kolchanov Nikolay A
Abstract excerpt
Evolutionary trends have been examined in 146 HIV-1 forms (2662 copies, 2311 isolates) polymorphic for the TATA box using the "DNA sequence-->affinity for TBP" regression (TBP is the TATA binding protein). As a result, a statistically significant excess of low-affinity TATA box HIV-1 variants corresponding to a low level of both basal and TAT-dependent expression and, consequently, slow replication of HIV-1 have...
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