Article
Gene-gene interactions of drug metabolizing enzymes and transporter protein in the risk of upper aerodigestive tract cancers among Indians.
Cancer epidemiology - 1 Oct 2010
Sam Soya Sisy, Thomas Vinod, Reddy Kanipakapatanam Sathyanarayana, Surianarayanan Gopalakrishnan, Chandrasekaran Adithan
Abstract excerpt
BACKGROUND: The combined genetic effects of single nucleotide polymorphisms may additively or synergistically contribute to the increased cancer risk. The interactions associated with xenobiotic metabolizing enzymes and transporter protein involved in the biotransformation and transport of xenobiotics could determine the functional outcomes over the independent effects of a single susceptibility gene in the risk...
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