Article
CYP1A1 polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population.
Head & neck - 1 Dec 2008
Sam Soya Sisy, Thomas Vinod, Reddy Sathyanarayana Kanipakapatanam, Surianarayanan Gopalakrishnan, Chandrasekaran Adithan
Abstract excerpt
BACKGROUND: The inter-individual differences in upper aerodigestive tract (UADT) cancer risk may be partly attributed to the polymorphic variability in the CYP1A1 gene that is involved in the metabolic activation of xenobiotics to carcinogenic reactive metabolites. METHODS: The hospital-based case-control study evaluated CYP1A1*2A and CYP1A1*2C polymorphisms in 408 histopathologically confirmed cases and 220...
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