Article
Interactions between cigarette smoking and polymorphisms of xenobiotic-metabolizing genes: the risk of oral leukoplakia.
Disease markers - 1 Jan 2013
Li Yu-Fen, Sung Fung-Chang, Tsai Ming-Hsui, Hua Chun-Hung, Liu Chiu-Shong, Huang Yao-Te, Yeh Chih-Ching
Abstract excerpt
BACKGROUND: This case-control study investigates the role of xenobiotic-metabolizing genes, including glutathione S-transferases (GSTs) and cytochrome P450 1A1 (CYP1A1) and 2E1 (CYP2E1), in the susceptibility to oral potentially malignant disorders (OPMDs). METHODS: The genotypes of GSTM1, GSTT1, GSTP1, CYP1A1*2C, and CYP2E1 PstI/RsaI polymorphisms were determined for 217 OPMD cases and 492 age- and sex-matched...
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