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Article

Mutual rescues between two dominant negative mutations in cardiac troponin I and cardiac troponin T.

The Journal of biological chemistry - 3 Sept 2010

Wei Bin, Gao Jimin, Huang Xu-Pei, Jin J-P

Abstract excerpt

Troponin T (TnT) and troponin I (TnI) are two evolutionarily and functionally linked subunits of the troponin complex that regulates striated muscle contraction. We previously reported a single amino acid substitution in the highly conserved TnT-binding helix of cardiac TnI (cTnI) in wild turkey hearts in concurrence with an abnormally spliced myopathic cardiac TnT (cTnT) (Biesiadecki, B. J., Schneider, K. L.,...

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Identifiers

PMID: 20551314
DOI: 10.1074/jbc.M110.137844
PMCID: PMC2934648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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