Cardiac troponin T variants produced by aberrant splicing of multiple exons in animals with high instances of dilated cardiomyopathy.

doi:10.1074/jbc.M206369200

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Article

Cardiac troponin T variants produced by aberrant splicing of multiple exons in animals with high instances of dilated cardiomyopathy.

The Journal of biological chemistry - 27 Dec 2002

Biesiadecki Brandon J, Elder Benjamin D, Yu Zhi-Bin, Jin Jian-Ping

Abstract excerpt

Adult cardiac muscle normally expresses a single cardiac troponin T (cTnT). As a potential pathogenic mechanism for turkey dilated cardiomyopathy, the splice-out of a normally constitutive exon generates an additional low molecular weight cTnT with altered conformation and function. We further found that aberrant splicing of cTnT also occurs in several mammals correlating to dilated cardiomyopathy. Skipping of...

Topics

Alternative Splicing
Amino Acid Sequence
Animals
Base Sequence
Cardiomyopathy, Dilated
Cats
Cloning, Molecular
DNA Primers
Disease Models, Animal
Dogs
Exons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Guinea Pigs

Humans

Isoproterenol

Mammals

Mice

Mice, Transgenic

Source

Open in PubMed

Identifiers

PMID: 12377784
DOI: 10.1074/jbc.M206369200

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