Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of troponin T mutations in familial hypertrophic cardiomyopathy on regulatory functions of other troponin subunits.

Journal of biochemistry - 1 Jul 2001

Takahashi-Yanaga F, Ohtsuki I, Morimoto S

Abstract excerpt

We have previously shown that mutations in troponin T (TnT), which is associated with familial hypertrophic cardiomyopathy (HCM), cause an increase in the Ca(2+) sensitivity and a potentiation of cardiac muscle contraction. To gain further insight into the patho-physiological role of these mutations, four mutations (Arg92Gln, Phe110Ile, Glu244Asp, Arg278Cys) were introduced into recombinant human cardiac TnT, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiomyopathy, Hypertrophic
Share to Myocardium
Share to Myofibrils

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Subunits

Share to Troponin

Share to Troponin C

Share to Troponin I

Share to Troponin T

Source

Identifiers

PMID: 11432788
DOI: 10.1093/oxfordjournals.jbchem.a002950

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of troponin T mutations in familial hypertrophic cardiomyopathy on regulatory functions of other troponin subunits.PMID 11432788Read ↗

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Altered regulation of cardiac muscle contraction by troponin T mutations that cause familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Different functional properties of troponin T mutants that cause dilated cardiomyopathy.Semantic proximity Read ↗

Familial hypertrophic cardiomyopathy mutations from different functional regions of troponin T result in different effects on the pH and Ca2+ sensitivity of cardiac muscle contraction.Semantic proximity Read ↗

Functional consequences of troponin T mutations found in hypertrophic cardiomyopathy.Semantic proximity Read ↗

Functional aberration of myofibrils by cardiomyopathy-causing mutations in the coiled-coil region of the troponin-core domain.Semantic proximity Read ↗

Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Alterations in thin filament regulation induced by a human cardiac troponin T mutant that causes dilated cardiomyopathy are distinct from those induced by troponin T mutants that cause hypertrophic cardiomyopathy.Semantic proximity Read ↗

Functional changes in troponin T by a splice donor site mutation that causes hypertrophic cardiomyopathy.Semantic proximity Read ↗

Functional analyses of troponin T mutations that cause hypertrophic cardiomyopathy: Insights into disease pathogenesis and troponin functionSemantic proximity Read ↗

Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy.Semantic proximity Read ↗

Role of troponin T in disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.