Article
Mutations in the circadian gene CLOCK in colorectal cancer.
Molecular cancer research : MCR - 1 Jul 2010
Alhopuro Pia, Björklund Mikael, Sammalkorpi Heli, Turunen Mikko, Tuupanen Sari, Biström Mia, Niittymäki Iina, Lehtonen Heli J, Kivioja Teemu, Launonen Virpi, Saharinen Juha, Nousiainen Kari, Hautaniemi Sampsa, Nuorva Kyösti, Mecklin Jukka-Pekka, Järvinen Heikki, Orntoft Torben, Arango Diego, Lehtonen Rainer, Karhu Auli, Taipale Jussi, Aaltonen Lauri A
Abstract excerpt
The circadian clock regulates daily variations in physiologic processes. CLOCK acts as a regulator in the circadian apparatus controlling the expression of other clock genes, including PER1. Clock genes have been implicated in cancer-related functions; in this work, we investigated CLOCK as a possible target of somatic mutations in microsatellite unstable colorectal cancers. Combining microarray gene expression...
Topics
- Adenocarcinoma
- Amino Acid Sequence
- Base Sequence
- CLOCK Proteins
- Cell Line, Tumor
- Colorectal Neoplasms
- Frameshift Mutation
- Gene Expression Profiling
- HCT116 Cells