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Article

Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes.

Aging - 1 May 2011

Yu Elizabeth A, Weaver David R

Abstract excerpt

The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent...

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Identifiers

PMID: 21566258
DOI: 10.18632/aging.100323
PMCID: PMC3156599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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