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Article

Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes.

Aging - 1 May 2011

Yu Elizabeth A, Weaver David R

Abstract excerpt

The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent...

Topics

Aging
Circadian Clocks
Circadian Rhythm
Gene Expression Regulation
Humans
Light
Neoplasms
Periodicity
Phenotype
Trans-Activators

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21566258
DOI: 10.18632/aging.100323
PMCID: PMC3156599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21566258-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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