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Article

Clinical Implications of Gene Dosage and Gene Expression Patterns in Diploid Breast Carcinoma

15 Jun 2010

Abstract excerpt

PURPOSE: Deregulation of key cellular pathways is fundamental for the survival and expansion of neoplastic cells. In cancer, regulation of gene transcription can be mediated in a variety of ways. The purpose of this study was to assess the impact of gene dosage on gene expression patterns and the effect of other mechanisms on transcriptional levels, and to associate these genomic changes with clinicopathologic...

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PMID: 20551037
DOI: 10.1158/1078-0432.ccr-10-0889

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