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Integration of DNA Copy Number Alterations and Prognostic Gene Expression Signatures in Breast Cancer Patients

12 Jan 2010

Abstract excerpt

PURPOSE: Several prognostic gene expression profiles have been identified in breast cancer. In spite of this progress in prognostic classification, the underlying mechanisms that drive these gene expression patterns remain unknown. Specific genomic alterations, such as copy number alterations, are an important factor in tumor development and progression and are also associated with changes in gene expression....

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PMID: 20068109
DOI: 10.1158/1078-0432.ccr-09-0709

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