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Article

Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2005

Sihto Harri, Puputti Marjut, Pulli Laura, Tynninen Olli, Koskinen Walter, Aaltonen Leena-Maija, Tanner Minna, Böhling Tom, Visakorpi Tapio, Bützow Ralf, Knuuttila Aija, Nupponen Nina N, Joensuu Heikki

Abstract excerpt

Mutations that may predict response to adenosine 5'-triphosphate (ATP)-mimetic epidermal growth factor receptor (EGFR) inhibitors occur in the EGFR kinase domain in lung adenocarcinomas and bronchioloalveolar carcinomas (BACs). Data on the frequency of EGFR mutations are sparse in other human tumors. Apart from the deletion mutant EGFRvIII, little is known about the frequency of mutations that encode for the EGFR...

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Source

Identifiers

PMID: 16133419
DOI: 10.1007/s00109-005-0699-4

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors.PMID 16133419Read ↗

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