Article
From gene to carcinogen: a rapidly evolving field in molecular epidemiology.
Cancer research - 1 Jul 1991
Jones P A, Buckley J D, Henderson B E, Ross R K, Pike M C
Abstract excerpt
Chemical and physical carcinogens leave footprints of their activities on DNA because of the patterns of base changes they induce. Additionally, the conversion of 5-methylcytosine to thymine in CpG sequences leads to a characteristic mutation which can be used to estimate the contribution of endogenous processes to human mutations. Knowledge of the pattern mutations found in genes commonly mutated in human...
Topics
- Carcinogens
- DNA Damage
- DNA, Neoplasm
- Genes
- Humans
- Mutation
- Neoplasms
- Tumor Suppressor Protein p53