Article
From gene to carcinogen: a rapidly evolving field in molecular epidemiology.
Cancer research - 1 Jul 1991
Jones P A, Buckley J D, Henderson B E, Ross R K, Pike M C
Abstract excerpt
Chemical and physical carcinogens leave footprints of their activities on DNA because of the patterns of base changes they induce. Additionally, the conversion of 5-methylcytosine to thymine in CpG sequences leads to a characteristic mutation which can be used to estimate the contribution of endogenous processes to human mutations. Knowledge of the pattern mutations found in genes commonly mutated in human...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
