Article
B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2010
Irish Jonathan M, Myklebust June H, Alizadeh Ash A, Houot Roch, Sharman Jeff P, Czerwinski Debra K, Nolan Garry P, Levy Ronald
Abstract excerpt
Human tumors contain populations of both cancerous and host immune cells whose malignant signaling interactions may define each patient's disease trajectory. We used multiplexed phospho-flow cytometry to profile single cells within human follicular lymphoma tumors and discovered a subpopulation of lymphoma cells with impaired B cell antigen receptor (BCR) signaling. The abundance of BCR-insensitive cells in each...
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