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Article

Single-cell analysis can define distinct evolution of tumor sites in follicular lymphoma

16 Mar 2021

Abstract excerpt

Tumor heterogeneity complicates biomarker development and fosters drug resistance in solid malignancies. In lymphoma, our knowledge of site-to-site heterogeneity and its clinical implications is still limited. Here, we profiled 2 nodal, synchronously acquired tumor samples from 10 patients with follicular lymphoma (FL) using single-cell RNA, B-cell receptor (BCR) and T-cell receptor sequencing, and flow...

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PMID: 33728464
DOI: 10.1182/blood.2020009855

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