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Article

Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scrapie strains within Europe.

The Journal of general virology - 1 Oct 2010

González Lorenzo, Sisó Sílvia, Monleón Eva, Casalone Cristina, van Keulen Lucien J M, Balkema-Buschmann Anne, Ortiz-Peláez Angel, Iulini Barbara, Langeveld Jan P M, Hoffmann Christine, Badiola Juan J, Jeffrey Martin, Acín Cristina

Abstract excerpt

Variability of pathological phenotypes within classical sheep scrapie cases has been reported for some time, but in many instances it has been attributed to differences in the PRNP genotype of the host. To address this issue we have examined by immunohistochemistry (IHC) and Western blotting (WB)...

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Source

Identifiers

PMID: 20538906
DOI: 10.1099/vir.0.022574-0

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20538906-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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