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Article

Distinction of scrapie phenotypes in sheep by lesion profiling.

Journal of comparative pathology - 1 Jul 2002

Ligios C, Jeffrey M, Ryder S J, Bellworthy S J, Simmons M M

Abstract excerpt

Major determinants of the pathological phenotype of natural scrapie are considered to be the agent strain and host prion protein (PrP) genotype, but the relationship between these is far from clear. Little is known about the strains that produce natural scrapie. A method of brain vacuolation profiling was developed which enables this aspect of disease phenotype to be characterized in detail. This method...

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Identifiers

PMID: 12354545
DOI: 10.1053/jcpa.2002.0589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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