Article
Prion protein gene variability in Spanish goats. Inference through susceptibility to classical scrapie strains and pathogenic distribution of peripheral PrP(sc.).
PloS one - 1 Jan 2013
Acín Cristina, Martín-Burriel Inmaculada, Monleón Eva, Lyahyai Jaber, Pitarch José Luis, Serrano Carmen, Monzón Marta, Zaragoza Pilar, Badiola Juan José
Abstract excerpt
Classical scrapie is a neurological disorder of the central nervous system (CNS) characterized by the accumulation of an abnormal, partially protease resistant prion protein (PrP(sc)) in the CNS and in some peripheral tissues in domestic small ruminants. Whereas the pathological changes and genetic susceptibility of ovine scrapie are well known, caprine scrapie has been less well studied. We report here a...
Topics
- Alleles
- Animals
- Autopsy
- Case-Control Studies
- Gene Frequency
- Genetic Predisposition to Disease
- Genetic Variation
- Goat Diseases
- Goats
- Haplotypes
- Immunohistochemistry
- Neurons
- Polymorphism, Genetic