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The association of 5-HTTLPR genotype and depressive symptoms is moderated by physical activity.

Journal of psychiatric research - 1 Feb 2011

Rethorst Chad D, Landers Daniel M, Nagoshi Craig T, Ross Julianna T D

Abstract excerpt

The s allele serotonin transporter polymorphic region (5-HTTLPR) is associated with a number of physiological mechanisms that may increase the risk of elevated depressive symptoms. However, reports of a relationship between serotonin transporter polymorphic region (5-HTTLPR) genotype and depressive symptoms have thus far been inconclusive. This heterogeneity of results suggests that other factors may be...

Topics

Adolescent
Depression
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Models, Genetic
Motor Activity
Polymorphism, Genetic
Serotonin Plasma Membrane Transport Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Young Adult

Source

Identifiers

PMID: 20538286
DOI: 10.1016/j.jpsychires.2010.05.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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