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Inflammatory response and parasite regulation in acute toxoplasmosis: the role of P2X7 receptor in controlling virulent atypical genotype strain of Toxoplasma gondii.

Frontiers in immunology - 1 Jan 2024

Prado-Rangel Thuany, Moreira-Souza Aline Cristina Abreu, da Silva Sthefani Rodrigues Batista, Barboza-Araujo Thais, Castro-Junior Archimedes Barbosa, Ramos Isalira Peroba Rezende, Takiya Christina Maeda, Vommaro Rossiane Claudia, Coutinho-Silva Robson

Abstract excerpt

Toxoplasmosis is a globally significant disease that poses a severe threat to immunocompromised individuals, especially in Brazil, where a high prevalence of virulent and atypical strains of Toxoplasma gondii is observed. In 1998, the EGS strain, exhibiting a unique infection phenotype, was isolated in Brazil, adding to the complexity of strain diversity. The P2X7 receptor is critical in inflammation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39267751
DOI: 10.3389/fimmu.2024.1452828
PMCID: PMC11390460

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