Article
Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis.
The Journal of infectious diseases - 1 Jan 2013
Dutra Míriam S, Béla Samantha R, Peixoto-Rangel Alba L, Fakiola Michaela, Cruz Ariane G, Gazzinelli Andrea, Quites Humberto F, Bahia-Oliveira Lilian M G, Peixe Ricardo G, Campos Wesley R, Higino-Rocha Anna C, Miller Nancy E, Blackwell Jenefer M, Antonelli Lis R, Gazzinelli Ricardo T
Abstract excerpt
Retinochoroiditis manifests in patients infected with Toxoplasma gondii. Here, we assessed 30 sibships and 89 parent/case trios of presumed ocular toxoplasmosis (POT) to evaluate associations with polymorphisms in the NOD2 gene. Three haplotype-tagging single-nucleotide polymorphisms (tag-SNPs) within the NOD2 gene were genotyped. The family-based association test showed that the tag-SNP rs3135499 is associated...
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