Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis.

doi:10.1371/journal.pone.0002285

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Article

Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis.

PloS one - 4 Jun 2008

Jamieson Sarra E, de Roubaix Lee-Anne, Cortina-Borja Mario, Tan Hooi Kuan, Mui Ernest J, Cordell Heather J, Kirisits Michael J, Miller E Nancy, Peacock Christopher S, Hargrave Aubrey C, Coyne Jessica J, Boyer Kenneth, Bessieres Marie-Hélène, Buffolano Wilma, Ferret Nicole, Franck Jacqueline, Kieffer François, Meier Paul, Nowakowska Dorota E, Paul Malgorzata, Peyron François, Stray-Pedersen Babill, Prusa Andrea-Romana, Thulliez Philippe, Wallon Martine, Petersen Eskild, McLeod Rima, Gilbert Ruth E, Blackwell Jenefer M

Abstract excerpt

BACKGROUND: Primary Toxoplasma gondii infection during pregnancy can be transmitted to the fetus. At birth, infected infants may have intracranial calcification, hydrocephalus, and retinochoroiditis, and new ocular lesions can occur at any age after birth. Not all children who acquire infection in utero develop these clinical signs of disease. Whilst severity of disease is influenced by trimester in which...

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PMID: 18523590
DOI: 10.1371/journal.pone.0002285
PMCID: PMC2390765

Genes

ABCA4

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