Article
TNFα rs1799964 TT genotype may be a susceptibility factor for vertical transmission of Toxoplasma gondii and clinical signs in newborns from pregnant women with acute toxoplasmosis.
Molecular biology reports - 1 Jun 2022
Bonifácio Lillian Gonzalez, Melo Mirele, Ayo Christiane Maria, Assoni Letícia Carolina Paraboli, Olímpio Larissa Martins, Nogueira Mariana Reis, Spegiorin Lígia Cosentino Junqueira Franco, Barbosa Deusenia Machado Ulisses, de Mattos Luiz Carlos, Pereira-Chioccola Vera Lucia, Brandão Cinara Cássia
Abstract excerpt
BACKGROUND: One of the main impacts of Toxoplasma gondii infection occurs during pregnancy and is related to the vertical transmission of the parasite (congenital toxoplasmosis), which can cause severe clinical outcomes and fetal death. During acute infection, in order to control the rapid replication of tachyzoites, different host immune response genes are activated, and these include cytokine-encoding genes....
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