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Article

hTERT promoter activity and CpG methylation in HPV-induced carcinogenesis

9 Jun 2010

Abstract excerpt

BACKGROUND: Activation of telomerase resulting from deregulated hTERT expression is a key event during high-risk human papillomavirus (hrHPV)-induced cervical carcinogenesis. In the present study we examined hTERT promoter activity and its relation to DNA methylation as one of the potential mechanisms underlying deregulated hTERT transcription in hrHPV-transformed cells. METHODS: Using luciferase reporter assays...

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Share to Telomeres, Telomerase, and Senescence
Share to Cervical Cancer and HPV Research
Share to Epigenetics and DNA Methylation

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PMID: 20534141
DOI: 10.1186/1471-2407-10-271

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