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Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations.

Phytochemistry - 1 May 2015

Sirikantaramas Supaart, Meeprasert Arthitaya, Rungrotmongkol Thanyada, Fuji Hideyoshi, Hoshino Tyuji, Sudo Hiroshi, Yamazaki Mami, Saito Kazuki

Abstract excerpt

DNA topoisomerase I (Top1) catalyzes changes in DNA topology by cleaving and rejoining one strand of the double stranded (ds)DNA. Eukaryotic Top1s are the cellular target of the plant-derived anticancer indole alkaloid camptothecin (CPT), which reversibly stabilizes the Top1-dsDNA complex. However, CPT-producing plants, including Camptotheca acuminata, Ophiorrhiza pumila and Ophiorrhiza liukiuensis, are highly...

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Identifiers

PMID: 25733498
DOI: 10.1016/j.phytochem.2015.02.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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