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Article

Molecular principle of topotecan resistance by topoisomerase I mutations through molecular modeling approaches.

Journal of chemical information and modeling - 22 Apr 2013

Pan Peichen, Li Youyong, Yu Huidong, Sun Huiyong, Hou Tingjun

Abstract excerpt

Originally isolated from natural products, camptothecin (CPT) has provided extensive playing fields for the development of antitumor drugs. Two of the most successful analogs of CPT, topotecan and irinotecan, have been approved by the FDA for the treatment of colon cancer and ovarian cancer, as well as other cancers. However, the emergence of drug resistance mutations in topoisomerase I is a big challenge for the...

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Share to Antineoplastic Agents, Phytogenic
Share to DNA Topoisomerases, Type I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23521602
DOI: 10.1021/ci400066x

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