Article
Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background.
BMC genomics - 7 Jun 2010
Noyes Harry A, Agaba Morris, Anderson Susan, Archibald Alan L, Brass Andy, Gibson John, Hall Laurence, Hulme Helen, Oh Sung Jong, Kemp Stephen
Abstract excerpt
BACKGROUND: Differences in gene expression may be caused by nearby DNA polymorphisms (cis regulation) or by interactions of gene control regions with polymorphic transcription factors (trans regulation). Trans acting loci are much harder to detect than cis acting loci and their effects are much m...
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