Detection of parent-of-origin effects in complete and incomplete nuclear families with multiple affected children using multiple tightly linked markers.

Abstract excerpt

For a diallelic marker locus, the parental-asymmetry test (PAT) based on case-parents trios and its extensions to accommodate incomplete unclear families (1-PAT and C-PAT) are simple and powerful approaches to test for parent-of-origin effects. However, haplotype analysis is generally regarded as advantageous over single-marker analysis in genetic study of common complex diseases. This is mainly due to the fact...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to Genetic Diseases, Inborn