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<i>In vivo</i> hepatic endoplasmic reticulum stress in patients with chronic hepatitis C

24 Feb 2010

Abstract excerpt

In hepatocytes, the accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and the unfolded protein response (UPR), mediated by the ER-resident stress sensors ATF-6, IRE1, and PERK. UPR-responsive genes are involved in the fate of ER-stressed cells. Cells carrying hepatitis C virus (HCV) subgenomic replicons exhibit in vitro ER stress and suggest that HCV inhibits the UPR. Since in...

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PMID: 20527020
DOI: 10.1002/path.2703

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