Article
C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle.
Journal of hepatology - 1 Sept 2020
Kinast Volker, Plociennikowska Agnieszka, Anggakusuma, Bracht Thilo, Todt Daniel, Brown Richard J P, Boldanova Tujana, Zhang Yudi, Brüggemann Yannick, Friesland Martina, Engelmann Michael, Vieyres Gabrielle, Broering Ruth, Vondran Florian W R, Heim Markus H, Sitek Barbara, Bartenschlager Ralf, Pietschmann Thomas, Steinmann Eike
Abstract excerpt
BACKGROUND & AIMS: HCV is a positive-strand RNA virus that primarily infects human hepatocytes. Recent studies have reported that C19orf66 is expressed as an interferon (IFN)-stimulated gene; however, the intrinsic regulation of this gene within the liver as well as its antiviral effects against HCV remain elusive. METHODS: Expression of C19orf66 was quantified in both liver biopsies and primary human...
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